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Multi-scale modeling of protein and protein complexes

Decanato - Facoltà di scienze informatiche

Data d'inizio: 8 Febbraio 2010

Data di fine: 9 Febbraio 2010

The Faculty of Informatics is pleased to announce a seminar given by Andrea Cavalli

DATE:  Monday, February 8th, 2010
PLACE: USI Università della Svizzera italiana, room SI-008, Informatics building (Via G. Buffi 13)
TIME: 14.30

ABSTRACT:
The determination of the three-dimensional structure of proteins and protein complexes are fundamental for our understanding of their function in living cells. Several experimental and computational techniques have been developed to deepen our understanding of these fundamental processes at different time scales and with various degrees of resolutions.  

For example, genome and proteome dynamics can be investigated using high-throughput sequencing and micoarray technologies. On a smaller scale, nuclear magnetic resonance (NMR) and X-ray crystallography have proven very successful in the determination of protein structures at an atomistic resolution.
In my talk I will focus on the key challenge to develop computer-based  methods that integrate heterogeneous sources of structural and dynamic information into a unified modeling framework, with the long-term goal, to obtain a comprehensive description of the processes inside living cells.

BIO:
I'm currently working in the groups of Chris Dobson and Michele Vendruscolo at the Chemistry Department of the University of Cambridge.
My research is focused on the development of computational methods for the determination of the structure and dynamics of proteins from NMR experimental data (chemical shifts, NOE, etc.) and, in collaboration with Beat Meier (ETHZ), the development of automated assignment algorithms in solid-state NMR.

HOST: Prof. Mauro Pezzè