Modelling and Simulation of Transdermal Transport
Staff - Faculty of Informatics
Start date: 30 June 2014
End date: 1 July 2014
The Faculty of Informatics is pleased to announce a seminar given by Arne Nägel
DATE: Monday, June 30th, 2014
PLACE: USI Lugano campus, room SI-008, Informatics building (Via G. Buffi 13)
TIME: 16:30
ABSTRACT:
The skin is the largest organ of the body for humans and provides a variety of important functions.
On the one hand, it is a highly effective barrier protecting the body from various substances and pathogens from the environment. On the other hand, the skin transduces signals from the environment, regulates heat, controls evaporation, and stores lipids and water. Since in-vivo and in-vitro methods often suffer from ethical difficulties and/or economic and time constraints, a mathematical in-silico description of the barrier and its properties is a desirable goal. As structure and function in the skin are highly interwoven, modelling is essential for improving our quantitative and qualitative understanding of this biological system. In this talk we present a model for the skin as a barrier.
The mathematical focus is on multiscale aspects, upscaling, and numerical methods and algorithms.
These tools allow to identify, e.g, which influence geometric factors, such as the cell shape, or the horizontal overlap of the cells, have on the barrier properties. Comparisons and validations to studies conducted by experimental collaborators are also provided. Finally, we comment on experimentally observed asymmetries of the membrane with respect to interior and exterior. This allows hypothesizing effects which have not been accessible experimentally yet.
BIO:
EDUCATION
2010 Dr. rer. nat, Ruprecht-Karls-Universität Heidelberg
2005 Diplom (M.Sc.) in Mathematics, Ruprecht-Karls-Universität Heidelberg
PROFESSIONAL EXPERIENCE
10.2008 - present Research Associate (Goethe-University Frankfurt)
08.2006 - 09.2008 Research Assistant (Ruprecht-Karls-Universität Heidelberg)
10.2005 - 07.2006 Researcher (Steinbeis Forschungsinsitut „Simulation in Technology", Heidelberg)
Summer 2002/03 Summer Intern (Lawrence Livermore National Laboratory, USA)
HOSTS: Dr. Daniel Ruprecht and Prof. Rolf Krause
