Seminars at the Faculty of Informatics

Inter-subject variability in cardiac electrophysiology: Insights from experimentally-calibrated computer models

The Institute of Computational Science of the Faculty of Informatics is pleased to announce a seminar given by Blanca Rodriguez

DATE: Friday, October 24th 2014
PLACE: USI Lugano Campus, room A-24, Red Building (Via G. Buffi 13)
TIME: 14.30

The electrophysiological activity of hearts from individuals of the same species is qualitatively similar under physiological conditions, but they can exhibit significant inter-subject differences in pathology and following pharmacological action. The causes and modulators of inter-subject variability are however unknown. In this presentation, I will describe how we have developed and used advanced computational modelling of the heart to augment experimental and clinical investigations with the main aim of identifying key factors underlying the inter-subject variability of human hearts in health and disease.

Blanca Rodriguez is interested in investigating the causes and modulators of variability in the electrophysiological response of the heart to disease and therapies. The methodologies developed and applied by her team aim at embedding computational methods in cardiovascular research to augment experimental and clinical investigations ( Their research is supported by an established network of collaborators in academia and industry, who are world-leading experts in in vivo and in vitro cardiovascular medicine and pharmacology. Blanca is grateful for the generous funding received from the Welcome Trust, MRC, EPSRC, Royal Society, European Commission and British Heart Foundation to support her team's research.

Blanca holds a Welcome Trust Senior Research Fellowship in Basic Biomedical Science and is the Professor of Computational Medicine in the Department of Computer Science at the University of Oxford. Blanca is from Valencia, Spain, and she has been in Oxford since 2004. She was a Medical Research Council Career Development and Centenary Award Fellow at Oxford (2007-2013) and a postdoctoral research fellow with Prof. Natalia Trayanova at Tulane University in New Orleans, USA (2002-2004). She is an Electronics Engineer by training from the Universidad Politecnica de Valencia, where she also conducted her PhD in Bioelectronics with Prof. Chema Ferrero (1998-2001). In addition to a fulfilling research life, she also has a husband and three children who keep her busy and very happy.

HOSTS: Prof. Rolf Krause, Prof. Angelo Auricchio

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