Seminars at the Faculty of Informatics

Modelling and Simulation of Transdermal Transport

The Faculty of Informatics is pleased to announce a seminar given by Arne Nägel

DATE: Monday, June 30th, 2014

PLACE: USI Lugano campus, room SI-008, Informatics building (Via G. Buffi 13)

TIME: 16:30

 

ABSTRACT:

The skin is the largest organ of the body for humans and provides a variety of important functions.

On the one hand, it is a highly effective barrier protecting the body from various substances and pathogens from the environment. On the other hand, the skin transduces signals from the environment, regulates heat, controls evaporation, and stores lipids and water. Since in-vivo and in-vitro methods often suffer from ethical difficulties and/or economic and time constraints, a mathematical in-silico description of the barrier and its properties is a desirable goal. As structure and function in the skin are highly interwoven, modelling is essential for improving our quantitative and qualitative understanding of this biological system. In this talk we present a model for the skin as a barrier.

The mathematical focus is on multiscale aspects, upscaling, and numerical methods and algorithms.

These tools allow to identify, e.g, which influence geometric factors, such as the cell shape, or the horizontal overlap of the cells, have on the barrier properties. Comparisons and validations to studies conducted by experimental collaborators are also provided. Finally, we comment on experimentally observed asymmetries of the membrane with respect to interior and exterior. This allows hypothesizing effects which have not been accessible experimentally yet.

 

BIO:

EDUCATION
2010                Dr. rer. nat, Ruprecht-Karls-Universität Heidelberg

2005                Diplom (M.Sc.) in Mathematics, Ruprecht-Karls-Universität Heidelberg


PROFESSIONAL EXPERIENCE
 10.2008 -     present       Research Associate (Goethe-University Frankfurt)

08.2006 - 09.2008            Research Assistant  (Ruprecht-Karls-Universität Heidelberg)

10.2005 - 07.2006            Researcher (Steinbeis Forschungsinsitut Simulation in Technology", Heidelberg)

Summer 2002/03             Summer Intern  (Lawrence Livermore National Laboratory, USA)

 

HOSTS: Dr. Daniel Ruprecht and Prof. Rolf Krause

 

URL 1: http://www.inf.usi.ch